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Prozac (Fluoxetine) Explained: Long Half-Life, 2D6 Interactions, and When It Helps Most Prozac (fluoxetine) is an activating SSRI with a long half-life, which can help when adherence is tricky or fatigue is prominent. We cover why missing a dose is often less disruptive, how CYP2D6 inhibition affects drug–drug interactions, and when clinicians consider Prozac— including OCD treatment. Educational only; speak with your clinician about risks, dosing, and alternatives. #Prozac #Fluoxetine #SSRI #OC