San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona Cardinals. On San Francisco's opening series and on Guerendo's second carry,

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals. The team announced that

The San Francisco 49ers 2024 season is officially over after a Week 18 40-24 loss against the Arizona Cardinals. Unfortunately, the season finale came with one final trick up its sleeve as running back Isaac Guerendo was carted off the field early in the first quarter.