In their Week 11 matchup on Sunday at 4:05 PM ET, RB Isaac Guerendo and the San Francisco 49ers square off against the ...

ANALYSIS: San Francisco 49ers running back Isaac Guerendo has barely seen the field as a rookie. He is the RB63 for the year, ...

Guerendo had one carry for zero yards in Sunday's 23-20 win over Tampa Bay. With star tailback Christian McCaffrey (Achilles) returning to action and backup Jordan Mason (shoulder) healthy, Guerendo ...

Christian McCaffery felt good physically. He’ll wait until he has a chance to watch some tape before deciding how good he looked in his season debut.

San Francisco 49ers QB Brock Purdy connected with RB Christian McCaffrey in the team's Week 10 matchup. San Francisco 49ers ...

NFL. Clyde Edwards-Helaire opens up about PTSD and the incident that changed his life NFL. Dak Prescott likely facing season-ending surgery for Torn Hamstring Shanahan's strategy revolves around ...

San Francisco 49ers running back Isaac Guerendo joined the 49ers "You've Got Mail" podcast presented by Delta Dental to discuss his journey to the pros, the early contributions of the rookie class and ...

San Francisco 49ers running back Isaac Guerendo has looked like one of the most explosive backs in the NFL in his limited ...

John Lynch revealed what Christian McCaffrey's impending return might mean for backup San Francisco 49ers running backs Jordan Mason and Isaac Guerendo.

In Week 10, running back Isaac Guerendo and the San Francisco 49ers' rushing attack will square off against the Tampa Bay ...