All diseases exist on a continuum, and the damage often begins early—sometimes as soon as a child is weaned off breast milk ...

CME activities, cases, challenges, videos, and more teaching and learning tools from the New England Journal of Medicine.

A 61-year-old man presented with hypoxemic respiratory failure and shock 10 weeks after kidney transplantation. A purpuric rash was present on the abdomen. A diagnosis was made. What is the diagnosis?

Abstract. Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age. Chronic mild hypoxia (CMH; 8% O 2) triggers transient blood-brain barrier (BBB) disruption, an ...

Photodynamic therapy (PDT), a noninvasive cancer therapeutic method triggered by light, would lead to severe tumor hypoxia after treatment. Utilizing a hypoxia-activated prodrug, AQ4N, which only ...

The system could efficiently alleviate hypoxia in tumor environments for up to 7 days, meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. Besides, the generated ...

Exposure for rodents to chronic intermittent hypoxia is also used to mimic the cyclic pattern of hypoxemia observed in patients experiencing obstructive sleep apnea 143,144 —a condition complicated by ...

Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension, coronary heart disease, strokes and heart failure with a reduced ejection fraction. However, the association ...

Background It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix ...

Section 6 Hypoxia, hypoxaemia, hyperoxaemia, hypercapnia and the rationale of targeted oxygen therapy. Effects and risks of hypoxia/hypoxaemia and rationale for target oxygen saturation range.