A timely medical intervention in the form of a bone marrow transplant, medically known as hematopoietic stem cell ...

Edited by Joseph Kieber, The University of North Carolina at Chapel Hill, Chapel Hill, NC; received November 27, 2024; accepted January 7, 2025 ...

The AlloHeme test can be used to predict relapse after allogeneic HCT in patients with AML or MDS, data suggest.

Orca-T with reduced-intensity stem cell transplantation was a safe, feasible alternative to conventional transplant in blood cancers, per phase 1 data. Preliminary findings from the phase 1 study ...

By measuring small changes in mixed chimerism, AlloHeme demonstrated excellent performance characteristics with a hazard ratio (HR) of 40.5 (p<0.001) for relapse, and a clinically meaningful ...

After RIC, it is normal at first to have some of your donor stem cells and some of your own cells. This is called mixed chimerism. Eventually, all your blood and bone marrow should ideally be from ...

Reconstitution of germ cell fate from pluripotent stem cells provides an opportunity to understand the molecular underpinnings of germ cell development. Here, we established robust methods for induced ...

Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we ...

Hematopoietic stem and progenitor cells (HSPC) experience a functional decline in response to chronic inflammation or aging. Haploinsufficiency of A20, or TNFAIP3, an innate immune regulator, is ...

Tests conducted on a patient with somatic chimerism have led Chinese scientist to a new theory about how gender is determined Researchers have suggested the sex a person is could be based on ...