Suicide gene therapy with herpes simplex virus thymidine kinase (HSV-TK) and ganciclovir (GCV) is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase.
Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong ...
Sheth, associated with the city-based FRIGE Institute of Human Genetics, said that the prevalence of Lynch Syndrome is believed to be about one in every 300 people in the general population. "The ...
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