Tipoff is set for 7:30 p.m. ET from Madison Square Garden in New York City. The Knicks are favored by 7.5 points in the latest Pistons vs. Knicks odds, according to the SportsLine consensus. The over/under is 223 points. Before entering any Knicks vs. Pistons picks, you'll want to see the NBA predictions from the model at SportsLine.

The Pistons are currently 10-10 on the road with a point differential of -1, while the Knicks have a 6-4 record in their last ten games at home.

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Knicks center Karl-Anthony Towns has a bone chip in his right thumb to go along with the sprain he suffered in Monday's loss, sources confirmed.

The word became official about 90 minutes before game time, but was predictable nearly 48 hours earlier that Karl-Anthony Towns would be out of action Wednesday night as the Knicks took on the Philadelphia 76ers at the Wells Fargo Center.