Familial pulmonary fibrosis represented 13% of fibrotic ILD overall, with higher proportions in IPF (18%) and unclassifiable ILD (15%) than in SARD-ILD (9%). Across diagnostic subgroups, familial ...

Achieving a confident diagnosis of IPF is challenging. Current guidelines recommend the exclusion of known causes for pulmonary fibrosis and the presence of a UIP pattern on HRCT or surgical lung ...

Interstitial lung disease (ILD) refers to a heterogeneous lung disease characterized by a combination of inflammation and fibrosis. In recent years, studies have identified effective antifibrotic ...

A biomarker panel for IPF may identify RA patients at higher risk for ILD, supporting biological overlap between IPF and RA-ILD. The study involved over 2500 US veterans and showed strong associations ...

Idiopathic pulmonary fibrosis stands as one of medicine’s most challenging respiratory conditions, gradually transforming healthy lung tissue into stiff, scarred material that severely compromises ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

IPF has an insidious onset. It often presents with persistent dry cough associated with worsening breathlessness and progressive decline in one's exercise capacity. Hemoptysis (coughing up blood) is ...

Multiphoton microscopy can help quantify collagen signatures, thereby mapping the fibrotic microenvironment in idiopathic pulmonary fibrosis.

On HRCT, a UIP pattern is characterized by the following features: 1) subpleural, basal predominance, 2) reticular abnormality, and 3) honeycombing. Typically, honeycombing occurs as clustered air ...