LOS ANGELES—Could the main character in the animated feature Rango have been inspired by Jack Sparrow in Pirates of the Caribbean? That’s Johnny Depp’s theory. Watch the trailer for Rango.

As the titular character of the animated film Rango (which opens March 4), he provides the vocal work for the character of a domesticated lizard who suddenly finds himself stranded in the desert ...

When Rango, a lost family pet, accidentally winds up in the gritty, gun-slinging town of Dirt, the less-than-courageous lizard suddenly finds he stands out. Welcomed as the last hope the town has ...