New Fix for 'Silent Aftershock' of Prostate Cancer Surgery

Men with prostate cancer have a major decision to make: whether to get a lifesaving surgery. Radical prostatectomy, the ...
MedPage Today

In Newly Diagnosed Prostate Cancer, Detecting Variants in Homologous Recombination Repair Genes

Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...
ascopubs.org

Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations

CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors A total of 109 patients with ...
ascopubs.org

Evaluation of homologous recombination repair (HRR) status in metastatic prostate cancer by next-generation sequencing and functional tissue-based immunofluorescence assays.

Exploration of circulating tumor cell (CTC) conversion and CTC0 as prognostic biomarkers for efficacy in TALAPRO-2: Phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as ...