Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict. Researchers at the Institute for ...

ReD, a method that adds repulsive forces between predicted structures, enabling AlphaFold3 to sample diverse protein ...

A protein's function is determined by its structure, and structure—the way a protein folds—is determined by its sequence of ...

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, including pharmaceuticals, industrial enzymes, and diagnostic antibodies.

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome. Yet despite decades of research, scientists still ...

AI systems have recently had a lot of success in one key aspect of biology: the relationship between a protein’s structure and its function. These efforts have included the ability to predict the ...

Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level ...