Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Adapted from an article by Robert Sanders at UC Berkeley. Nearly 100 years ago, a discovery revolutionized light microscopy. The introduction of the phase-contrast microscope, which garnered a Nobel ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...