Notch-1 inhibits apoptosis in some transformed cells through incompletely understood mechanisms. Notch-1 can increase nuclear factor-kappa B (NF-κB) activity through a variety of mechanisms.
Notch genes encode heterodimeric transmembrane receptors that regulate differentiation, proliferation and apoptosis 1,2. Mammals have four known Notch genes and two families of Notch ligands ...
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