Neurodegenerative diseases affect millions of people worldwide and as our life expectancy increases, more individuals are expected to be affected in the coming decades. Tauopathies such as Alzheimer’s ...

In their efforts to pick up the disease as early as possible, scientists are searching far and wide through the human body for tell tale signs of Alzheimer’s. A team from the Washington University ...

Voyager Therapeutics, Inc. has announced that it will present eight oral and poster presentations at the American Society of Gene & Cell Therapy's upcoming annual meeting, focusing on its innovative ...

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer’s disease, and improve symptoms of neurodegeneration in mice. The ...

Tau proteins, when tangled inside of neurons, are central to neurodegenerative diseases like Alzheimer's and have been one of the leading targets among drug developers. Now, researchers say they've ...

The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the ...

In neurons, tau pulls methylated RNA, RNA-binding proteins, into cytosol. Knocking down the RNA and RBPs quelled tangles in mouse brain. In AD brain, methyl-RNA amasses in tangles as disease worsens.

Aducanumab (Aduhelm), the only monoclonal antibody approved by the US Food and Drug Administration (FDA) for the treatment of Alzheimer's disease (AD), removes amyloid from the brain and reduces ...

Researchers used microscopy and machine learning to distinguish tau protein aggregates occurring as part of healthy functions from those occurring in disease. It turns out that not all build-ups of ...