Melanoma is the deadliest form of skin cancer, and cases are rising. Since 2000, diagnoses in the U.S. have increased from 18 ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of ...

the team observed that blocking this signaling pathway also enhances the response to immunotherapy in preclinical mouse models. "Immune checkpoint inhibitors have revolutionized melanoma treatment ...

Until recently, uveal melanoma was a disease that was poorly ... the side effects from previous drugs that work along this pathway, such as hyperglycemia, dermatitis and rash, stomatitis ...

Cancer-associated fibroblasts (CAFs) play an important role in metastatic melanoma, and an enhanced understanding of that role could lead to important new therapeutic pathways, according to a new ...

Researchers at the University of California San Diego have uncovered a key mechanism underlying the treatment resistance of melanoma with the BRAF V600E mutation through pathways involved in focal ...

Bristol Myers Squibb has reported disappointing results for its checkpoint inhibitor combination Opdualag in melanoma, dashing its hopes of moving the drug earlier in the treatment pathway.