A phase III trial of enzyme-replacement therapy for lysosomal acid lipase deficiency has shown the effectiveness and safety of sebelipase alfa, a recombinant lysosomal acid lipase. Lysosomal acid ...

Digestive enzymes are often used to support healthy digestion and increase nutrient absorption. Studies show that they may benefit conditions like lactose intolerance and irritable bowel syndrome (IBS ...

December 2, 2011 — Lysosomal storage disorders such as Fabry's disease and Pompe's disease are much more common than previously thought, particularly atypical later-onset forms, a new study suggests.

ST. LOUIS--(BUSINESS WIRE)--M6P Therapeutics (“M6PT” or “the Company”), a privately held life sciences company developing next-generation recombinant enzyme and gene therapies for lysosomal storage ...

This is a preview. Log in through your library . Abstract The sensitivity of cultured human and hamster fibroblast cells to killing by the lysosomotropic detergent N-dodecylimidazole ( C12- Im) was ...

Digestive enzymes play a crucial role in breaking down food into smaller, absorbable molecules, and certain foods can naturally supplement these enzymes. Fruits like pineapple, papaya, mangoes, and ...

A deficiency of β-galactosidase (pH 5.0) was found in frozen tissues (brain, liver, kidney and spleen) from 10 patients with Hurler's syndrome (Types 1–3). The diminished activity of this enzyme was ...

ST. LOUIS--(BUSINESS WIRE)--M6P Therapeutics, a privately held life sciences company developing next-generation recombinant enzyme and gene therapies for lysosomal storage disorders (LSDs), announced ...

(A) Due to PNPLA3 defects. Genetic defects in PNPLA3 result in decreased hydrolysis of triglycerides to fatty acids. This leads to increased intrahepatic triglycerides and decreased exportation of ...

The human body undergoes numerous changes throughout life, with many significant transitions occurring during the decade of the 40s. Among these changes, the decrease in digestive enzyme production ...