Desert Hedgehog signaling promotes stem Leydig cell differentiation through a Ptch2-Gli1-Sf1 regulatory axis in Nile tilapia.

Leydig cell lineage originates from multipotent mesenchymal precursors in the interstitial compartment of the testis. Development proceeds through distinct stages: undifferentiated stem Leydig cells ...

Leydig cells, located in the interstitial compartment of the testis, are the principal site of androgen biosynthesis. Steroidogenesis in these cells begins with cholesterol uptake and transport into ...

The COVID-19 virus hijacks the machinery of testicular cells that produce the hormone testosterone in order to replicate. It also appropriates the metabolic pathways of these cells and cholesterol, a ...

Direct assessment of Leydig cell function in childhood cancer survivors has been limited. The objectives of this study were to describe the prevalence of and risk factors for Leydig cell failure (LCF) ...

The effects of cannabis on the hormonal system and male fertility remain controversial within the scientific community. A study conducted by the University of Geneva (UNIGE), in collaboration with the ...