Accurate segregation of sister chromosomes during mitosis depends on the assembly of structural proteins at the kinetochore that link spindle microtubule plus-ends to centromeric DNA (CEN DNA). The ...

Protein kinase signaling along the kinetochore–centromere axis is crucial to assure mitotic fidelity, yet the details of its spatial coordination are obscure. Here, we examined how pools of human Polo ...

As a human cell begins division, its 23 chromosomes duplicate into identical copies that remain joined at a region called the centromere. Here lies the kinetochore, a complicated assembly of proteins ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...

The cell cycle, the biological process underlying how cells grow and multiply, is tightly regulated to ensure a faithful distribution of genetic material to ‘daughter’ cells. This tight regulation of ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...

Osaka, Japan – During cell division, chromosomes, i.e., molecules containing our genetic material, must be properly replicated and segregated so that each daughter cell receives a complete and ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...

Cell division is vital for the continuation of life. If something goes wrong in, say, the distribution of chromosomes, abnormalities or serious diseases such as cancer may result. This is why ...

It's a cellular process going on since one billion years, yet we are not able to replicate it, nor to fully understand it. Mitosis, the mechanism of cell division that is so important for life, ...