After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. The ...

To design drugs that stall the growth of aggressive cancers, it helps to know the structures of the proteins that are revving the cancers' engines. In a series of three papers published in Proceedings ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David ...