Chromatin is composed of nucleosomes, which consist of DNA and histone proteins. The histone amino terminus has a 'tail' region that is highly conserved between species and consists of protein modules ...

This is a preview. Log in through your library . Abstract DNA isolated from mammalian cell nuclei reveals discrete size patterns when partially digested with micrococcal nuclease. The DNA repeat ...

The vacuolar protein sorting 75 (Vps75) histone chaperone participates in chromatin assembly and disassembly at both active and inactive genes through the preferential binding to histone H3-H4. Vps75 ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

It takes a lot of packaging to squeeze DNA into the nucleus of a cell. The DNA in our chromosomes is packaged into nucleosomes, which consist of about 150 DNA base pairs wrapped around eight-protein ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

The story of cancer is, largely, one of broken genes. The valiant tumor suppressor, defender of cellular integrity, maimed and enfeebled. The conniving oncogene, hyper-activated, allowed to run wild ...

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA. Now, Warnecke and colleagues are challenging the idea that these ...

A research team led by Dr. Xiang David Li, Associate Professor from the Department of Chemistry, in collaboration with Dr. Karen Wing Yee Yuen from the School of Biological Sciences and Dr. Jason Wing ...