Tumor heterogeneity has been a major contributor to lethal outcomes, drug resistance, and therapeutic failures, and presents a key challenge to precision medicine goals 1,2. In light of the ...

There is large inter-individual heterogeneity in risk of coronary heart disease (CHD). Risk factors traditionally used in primary risk assessment only partially explain this heterogeneity. Residual, ...

A team of South Korean scientists led by Professor Kim Jae Kyoung of the Biomedical Mathematics Group within the Institute for Basic Science (IBS-BIMAG) discovered the secrets of cell variability in ...

Tumor heterogeneity refers to the presence of a variety of distinct cell types within a tumor. High tumor heterogeneity is thought to contribute to breast cancer progression and metastasis, or ...

In a recent article published in Nature Communications, researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity. AD is highly ...

Heterogeneity is ubiquitous in real-world host populations, yet most theories assume homogeneity. Using a metapopulation model, we examine how host heterogeneities, such as uneven movement patterns ...

The immune system possesses a plasticity that allows it to adapt to shifting threats. This plasticity is driven by cellular heterogeneity—where immune cells adopt different genotypes and phenotypes ...

Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA) The research and collaborative ...

Genomic landscapes of early-onset versus average-onset colorectal cancer populations. Evaluation of microsatellite instability status, a definitive predictive biomarker for immune checkpoint ...

A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of ...