The cytochromes P450 (CYPs) are the main enzyme family for metabolism of therapeutic drugs. CYP3A4 is the most active drug metabolizing CYP, and it plays a prominent role in adverse drug-drug ...

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for ...

The prominent role a single enzyme plays in cancer imaging has eluded researchers for years, but not anymore. This discovery could pave new avenues in nuclear medicine. The enzyme, called neutral ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An ...

Identification of a small-molecule inhibitor of Stat5a/b through structure-based screen for therapy development for prostate cancer. Background: Abiraterone is a novel inhibitor of the steroidogenic ...

Few studies have directly compared the renoprotective effects of angiotensin II–receptor blockers and angiotensin-converting–enzyme (ACE) inhibitors in persons with type 2 diabetes. In this ...

This is a preview. Log in through your library . Abstract The effects of various inhibitors of protein and nucleic acid synthesis on the development of invertase activity and increased nucleolar ...

Preclinical study showed PDIA1 and PDIA5 protect cells from oxidative stress, maintain mitochondrial function, and are ...

Criteria defining the duration of chemoreduction with focal treatment in retinoblastoma: A retrospective analysis. Background: Caffeine is a radio- and chemo-sensitizing agent acting by inhibiting ATM ...

This is a preview. Log in through your library . Abstract Time-courses of light-induced activities of enzymes relating to anthocyanin formation were studied. Phenylalanine ammonia-lyase (PAL), ...