Using nuclear magnetic resonance (NMR) spectroscopy, chemists have discovered how the structure of E. coli’s EmrE efflux pump—a transporter that can pump toxic molecules like antibiotics out of ...

Multidrug resistance in Gram-negative bacteria represents a major public health challenge, with these organisms evolving a myriad of mechanisms to evade the effects of antibiotic treatment. One ...

Researchers have used a combination of genetic manipulation and protein structural analysis to determine how the position of 'bulky' amino acids influences the ability of efflux pump inhibitors to ...

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

Researchers have isolated a compound from an Australian desert shrub with a long history of medicinal use by the Indigenous peoples of Australia that could help cancer patients better respond to ...

Bacterial infections are common and can impact various organs and tissues in the human body.² Clinicians typically prescribe antibiotics to treat these infections; however, many bacteria have ...

Scientists at Fujifilm Corp. and Osaka University have described piperazine derivatives acting as drug efflux pump inhibitors reported to be useful for the treatment of bacterial infections.

AMES, Iowa – Research teams led by Edward Yu of Iowa State University and the Ames Laboratory have described the structures of two proteins they believe pump antibiotics from bacteria, allowing the ...

Led by researchers from New York University, NYU Grossman School of Medicine, and NYU Langone's Laura and Isaac Perlmutter Cancer Center, the new study used advanced microscopy to "see" for the first ...

PRESS RELEASE AB SCIENCE ANNOUNCES A NEW PUBLICATION ON BIORXIV THAT IDENTIFIES AND CHARACTERIZES A NOVEL SMALL SYNTHETIC MOLECULE, AB8939, AS A PROMISING DRUG CANDIDATE FOR TREATING REFRACTORY ACUTE ...

image: The inhibitor-binding site of the wild-type MexB pump. (a) The crystal structure of the inhibitor ABI-PP bound to the MexB trimer. Three MexB monomers are shown in green, blue, and red, ...