The innate immune system recognizes nucleic acids during infection or tissue damage; however, the mechanisms of intracellular recognition of DNA have not been fully elucidated. Here we show that ...

TLR9 binding of DNA is complex and multifactorial 1,2,3,4. Microbial DNA is typically transported into intracellular compartments during the process of infection and triggers IFN-α production in pDCs ...