Circle Pharma announced publication of research in the Journal of Medicinal Chemistry highlighting optimization of oral cyclin A/B RxL inhibitors.

Cyclin D1, together with cyclin-dependent kinase (CDK) 4 and CDK6, promotes progression through the G 1 phase of the cell cycle by regulating retinoblastoma protein (pRb)/E2F function; this underlies ...

This study is carried out by Prof. Qiang Liu (Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University). In this study, researchers found that the palbociclib-resistant breast cancer ...

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply ...

Circle Pharma, a leader in macrocycle drug discovery and development, announced the submission of its first Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) ...

A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research. Cyclin D1, a protein that helps push a ...

Incidental lymphoma during sentinel lymph node biopsy for breast cancer. Background: To evaluate the cyclin D1 expression in breast cancer patients and to investigate its correlation with other ...

SOUTH SAN FRANCISCO, Calif., December 17, 2025--(BUSINESS WIRE)--Circle Pharma, Inc., a clinical-stage biopharmaceutical company pioneering next-generation targeted macrocycle therapeutics for cancer, ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Circle Pharma, Inc., a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, ...

The research, focused on the role of cyclin, one of the most important protein molecules needed for cell division. It describes the identification of three different types of cyclin in the parasite, ...