The host cell system is a critical determinant of recombinant protein quality and yield, with direct influence on protein folding and post-translational modification factors that shape the ...

Cell line development (CLD) follows a process that has only changed slightly since it was established in the early days of biopharmaceutical development. The steps to create a stable, manufacturing ...

Most research labs can make cells that produce antibodies. The trick is making those antibodies in sufficient quantity and quality to use throughout clinical trials and for manufacturing scale-up.

Preventing selection bias in the cell line is a critical aspect of cell line development. Selecting clones based on factors such as stability, antibody secretion, or other metrics can result in a ...

For the past 20 years, Abzena has built a strong reputation for producing high-yielding mammalian cell lines for protein targets. By applying the 2G UNic vector technology to their existing CHO ...

With three decades of experience, over 200 client partnerships and several cell-line development platforms, Aragen Bioscience supports its global biopharma clients with end-to-end biologics ...

Traditional approaches to biologics production—relying on one-size-fits-all expression vectors and empirical process optimization—have led to inefficiencies in expression, scalability, and ...