The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...

A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by ...

Fluorescence-guided tumor resection using a telomerase-dependent adenoviral GFP for cancer-specific labeling. Background: MX, the first base excision repair (BER) inhibitor evaluated in humans, blocks ...

Effects of TKI on patients with non-small cell lung cancer of different stages: A meta-analysis. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a ...

This is a preview. Log in through your library . Abstract CAG/CTG repeats are structure-forming repetitive DNA sequences, and expansion beyond a threshold of ∼35 CAG repeats is the cause of several ...

A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...

This is a preview. Log in through your library . Abstract Reactive oxygen species (ROS) have emerged as important cellular-signaling agents for cellular survival. Herein, we demonstrate that ...

Damage to your DNA is unavoidable. Every day our cells are bombarded by gene-splitting UV radiation or chemical carcinogens. Regular water inside our bodies can cause DNA damage. DNA damage is as ...

The native structure of genomic DNA can be damaged in many ways, both by external agents and from within the cell as a consequence of normal metabolism In an effort to maintain their genomic integrity ...

The Nobel prize in chemistry has gone to research showing how DNA fixes the damage that can cause cancer and premature ageing. Tomas Lindahl of the Francis Crick Institute in Hertfordshire, UK, Paul ...