Nature

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Figure 1: FPP synthesis and mevalonate pathway. In the present work, we determine a crystal structure of FPPS in complex with FPP. Intriguingly, the product is bound not to the active site, but to the ...
Business Wire

Ensem Therapeutics To Present Preclinical Data for Potential Best-in-Class Allosteric Pan-Mutant-Selective PI3Kα Inhibitor and Degrader at San Antonio Breast Cancer Symposium

WALTHAM, Mass.--(BUSINESS WIRE)--Ensem Therapeutics, Inc. (ENSEM), a pioneering drug discovery and development company that leverages its unique Kinetic Ensemble® platform to advance innovative small ...
C&EN

HotSpot Therapeutics debuts with $45 million to pursue allosteric inhibitors

HotSpot Therapeutics is debuting with $45 million from Atlas Venture and Sofinnova Partners to explore allosteric inhibitors against tough-to-drug targets. The Cambridge, Mass.-based biotech firm will ...
EurekAlert!

Enzymatic kinetics in an ultra-high-throughput format

DOMEK is a multi-step pipeline which leverages mRNA display-derived next-generation sequencing data to derive kinetic information about substrates of post-translational modification enzymes.