CLEVELAND, Ohio — The ⁠⁠⁠ ⁠Browns⁠ ⁠⁠⁠ return home on Sunday to host the San Francisco 49ers, a team fighting for the playoffs but also traveling cross-country on a short week to play in Cleveland. Rookie quarterback Shedeur Sanders will make his second consecutive start for the Browns.

The San Francisco 49ers’ final injury report is official. Here are the players ruled out for Sunday’s game against the Cleveland Browns, per Kyle Shanahan: Shanahan said Christian McCaffrey “needed” the extra rest with the 49ers playing the Monday night game, which is why McCaffrey didn’t practice this week.

The San Francisco 49ers will take on the Cleveland Browns on Sunday, and ahead of the game, they've elevated two players from their practice squad.

The 49ers are 4.5-point favorites, according to the latest Browns vs. 49ers odds. The over/under for total points scored is 36.5. Before making any Browns vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model.