In their Week 11 matchup on Sunday at 4:05 PM ET, RB Isaac Guerendo and the San Francisco 49ers square off against the ...

ANALYSIS: San Francisco 49ers running back Isaac Guerendo has barely seen the field as a rookie. He is the RB63 for the year, ...

This week, McCaffrey returned to practice looking as sharp as ever. Jordan Mason and rookie Isaac Guerendo have stepped up ...

Guerendo had one carry for zero yards in Sunday's 23-20 win over Tampa Bay. With star tailback Christian McCaffrey (Achilles) returning to action and backup Jordan Mason (shoulder) healthy, Guerendo ...

San Francisco 49ers rookie running back Isaac Guerendo’s coachability and maturity has played a big role in his steady ...

Isaac Guerendo is navigating his first NFL season, and though the San Francisco 49ers rookie running back has only logged 37 ...

Since joining the 49ers, Isaac Guerendo's rise to significant snaps came in the wake of injuries to star running backs Christian McCaffrey, Elijah ...

San Francisco 49ers running back Isaac Guerendo joined the 49ers "You've Got Mail" podcast presented by Delta Dental to ...

Guerendo rushed 14 times for 85 yards and a touchdown while securing three of four targets for 17 yards in Sunday's 30-24 win over Dallas. Guerendo took over mid-game after Jordan Mason (shoulder ...

Rookie running back Isaac Guerendo also shined with 85 yards on 14 carries and his first career touchdown after Jordan Mason exited the game early with a shoulder injury. Wide receiver Deebo ...

In Week 10, running back Isaac Guerendo and the San Francisco 49ers' rushing attack will square off against the Tampa Bay ...