Indiana coach Darian DeVries burned multiple timeouts in the opening minutes, but they didn’t do much to slow Louisville down. Isaac McKneely hit back-to-back 3-pointers to make it a 16-0 game much to the dismay of the many IU fans in attendance.

Louisville scored the first three points of the second half, but Indiana was able to slowly chip into their lead and threaten to come all the way back. A 14-8 stretch by the Hoosiers saw their deficit dip to as little as eight points at the 13:42 mark of the half.

Our Louisville vs. Indiana predictions think the Cardinals will get a much-needed big rebounding game from Sananda Fru.

Preview the Dec 6 matchup between the Louisville Cardinals and Indiana Hoosiers with how to watch, tv channel info, predictions, odds, over/under, spread, betting lines and more.

That area of the state is packed with fans of Indiana, Louisville and Kentucky with some Cincinnati mixed in, with differing conferences shifting relationships between schools over time. Indiana and Kentucky, as such, have a historic rivalry. So do Louisville and Kentucky. And Louisville and Cincinnati.

With both schools coming off their first loss, sixth-ranked Louisville and No. 22 Indiana will face a challenge getting back to their winning ways when they square off Saturday afternoon in Indianapolis.